0000009817 00000 n Here limiting reagent is salicylic acid; hence yield should be calculated from its amount taken. Figure 2: Synthesis of Aspirin Method of synthesis. Synthesis of aspirin from salicylic acid using acetic anhydride. Organic Synthesis International by Dr Anthony Melvin Crasto Ph.D, Worlddrugtracker, Million hits on google on all sites, One lakh connections worldwide.

Q.1 “2-acetoxybenzoic acid” is the IUPAC nomenclature of which drug? Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid.

Due to this, the pain producing prostaglandins production is prevented. Activity is abolished when the phenolic hydroxyl group is placed on meta or para position to the carboxyl group.

0000003046 00000 n 0000001504 00000 n

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Here limiting reagent is salicylic acid; hence yield should be calculated from its amount taken. (The product is obtained as colourless crystals, yield 11 g and m.p. Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid.

Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis, & Searle India ltd, now RPG lifesciences, etc. trailer << /Size 102 /Info 75 0 R /Root 77 0 R /Prev 190016 /ID[<2d4afc2c761e351bf9150f76bbe78a83><2d4afc2c761e351bf9150f76bbe78a83>] >> startxref 0 %%EOF 77 0 obj << /Type /Catalog /Pages 72 0 R >> endobj 100 0 obj << /S 298 /Filter /FlateDecode /Length 101 0 R >> stream

The purpose of adding sulphuric acid (catalyst) is to aid and augent the process of detaching the acetate ion (CH3COO–) from acetic anhydride which ultimately gets associated with H+ ion from phenolic hydroxy group in salicylic acid to be eliminated as a mole of acetic acid.1. Recrystallise the product from a mixture of equal volumes of water and acetic acid.

0000007424 00000 n He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc.

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In this experiment, phosphoric acid will be used as the catalyst. ABOUTME, BRAND ANTHONYCRASTO, COLLECTION OF SITE LINKS, BRAVESITES,GRAVATAR, JIMDO, SKILLPAGES, MIXXT,APNACIRCLE, ZIC ZAC, ZING ME, SCOOP IT, scribd, Stumbleupon,Delicious, pinnterest, tumblr, Newsvine, SLIDESHARE,ACADEMIA.EDU, GOOGLE PLUS, FACEBOOK, TWITTER, ISSUU,DIIGO, YOLASITE. SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Dissolve 10 g of salicylic acid (o-hydroxybenzoic acid) in dry pyridine (7 ml) in a conical flask of 100 ml. Q.6 Acetylation of salicylic acid leads to formation of which drug? Vogel’s text book of Practical Organic Chemistry, Page No. In 1893, German chemist Felix Hoffman synthesized an ester derivative of salicylic acid, acetylsalicylic acid (“aspirin”). 0000010832 00000 n Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (R-OH → R-OCOCH 3).

The reaction is proceeding... BACKGROUND Principle: This is a method of condensation of an aryl 1,2-diamine with a 1,2-dicarbonyl compound by heating in... BACKGROUND Principle: Aromatic aldehyde condense with aliphatic or mixed aryl alkyl ketone in presence of aqueous alkali to form... BACKGROUND Principle: The synthesis of barbituric acid is effected by condensation of diethyl malonate with urea in the presence... Production of alcohol from sugarcane Punit Tripathi, Vectors in Gene Cloning Plasmids Yogita Salgar, Bacterial growth curve cultivation of anaerobs Suman Kumar Mekap, Neuro Humoral Transmission Suman Kumar Mekap, Principles & Mechanism of Drug Action Suman Kumar Mekap.

,l��{�n�����W0 ɾ�����,ߝ��FO��R���s���\��>�r�|WwWJrJ���g�Y��d���f�P}y�e�J���w,�]�ȼ�|;�U��[�:�O}����C{e�\[m��y���Jc��ƃc���&[�ا����/6�s�з�N��˹o���1o[��軱ҵ���N��߾��\V�slZ�]�d�^����Q��ׁ}��2*24I�l�T)��He�-�lȒb;�:�)�k��$�HDKr�C�*H�L��צH�K�Rc^jKr3����w��r�G���y�·ΰ���S��,�yt_}Wnp��b�q3b���<_�X����;����r�b�-h�R#�����(Ǘ꒔�;��ԗ|��r���. Once Salicylic Acid (limiting reagent) is synthesized, it too can undergo a carbonyl addition-elimination with acetic anhydride to produce aspirin. Aim: To prepare aspirin from salicylic acid. 0000005241 00000 n %PDF-1.2 %���� Q.3 Match the following with correct classifications of the drugs. Molecular formula of salicylic acid = C7H6O3, Molecular formula of acetylsalicylic acid (aspirin) = C9H8O4, Molecular weight of salicylic acid = 138 g/mole, Molecular weight of acetyl salicylic acid (aspirin) = 180 g/mole, 138 g of salicylic acid gives 180 g of aspirin, Therefore, 6 g of salicylic acid will give ? 1290 no 522. The Beckmann rearrangement , named after the German chemist Ernst Otto Beckmann (1853–1923), is an acid-catalyzed rearrangement of an ... General procedure for the preparation of ten newly synthetized compounds - 2-(p-chlorophenyl)-3-methyl-4- (p-isopropylphenyl)-1,... . (adsbygoogle = window.adsbygoogle || []).push({}); We Labmonk, some scientific researchers unite to design a platform for getting sources of different lab protocols and discuss various research related issues. 0000006303 00000 n

He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . H 2 SO 4 (use a dropper, H2SO4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves. 0000008237 00000 n Molecular formula of salicylic acid = C7H6O3, Molecular formula of acetylsalicylic acid (aspirin) = C9H8O4, Molecular weight of salicylic acid = 138 g/mole, Molecular weight of acetyl salicylic acid (aspirin) = 180 g/mole, 138 g of salicylic acid gives 180 g of aspirin, Therefore, 6 g of salicylic acid will give ? Aim: To prepare aspirin from salicylic acid.

The heat of the reaction causes the temperature of the mixture to rise rapidly: therefore maintain the latter between 50° and 60° throughout the addition, cool the flask in cold water occasionally if necessary. Warm the mixture on water bath at 60 degrees about 20 min with frequent stirring.

This time the hydroxyl group of the salicylic acid acts as the nucleophile to attack the carbonyl group of the acetic anhydride and replace one of the acetyl groups. 76 0 obj << /Linearized 1 /O 78 /H [ 923 371 ] /L 191664 /E 11064 /N 22 /T 190026 >> endobj xref 76 26 0000000016 00000 n

Figure 2: Synthesis of Aspirin After the synthesis of aspirin, the product was recrystallized for … 0000001639 00000 n I. SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid.

0000004204 00000 n It is recommended for arthritis and related arthritic conditions, myocardial infarction prophylaxis. A small amount of a strong acid is used as a catalyst which speeds up the reaction. Aspirin is used for: Reducing fever; Relieve mild to moderate pain; Prevention of blood clotting; Reducing the risk of stroke; Reducing the risk of heart attack; As a blood thinner Side Effects Finally heat the mixture on a steaming water-bath for 5 min and after that cool in cold water, pour it in a thin stream into about 300 ml of cold water, stirring the mixture vigorously meanwhile. LTD. Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts. The purpose of adding sulphuric acid (catalyst) is to aid and augent the process of detaching the acetate ion (CH3COO–) from acetic anhydride which ultimately gets associated with H+ ion from phenolic hydroxy group in salicylic acid to be eliminated as a mole of acetic acid.1.

Currently he is working with GLENMARKPHARMA LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. 136-137 °C.). Substitution on the carboxyl or phenyl hydroxyl groups results in changes in the toxicity and potency of the drug. It is recommended for arthritis and related arthritic conditions, myocardial infarction prophylaxis. He has total 29 yrs exp in this field, he is now helping millions, has million hits on google on all organic chemistry websites. A password reset link will be sent to you by email. Aspirin can be synthesised by the acetylation of the salicylic acid by acetic anhydride or acetyl chloride. Heat for 10 min at 900C.

Add 8.5 ml acetic anhydride and 3-4 drops of concentrated sulphuric acid to the flask carefully and mix thoroughly. His New Drug Approvals , Green Chemistry International,Eurekamoments in Organic Chemistry , Organic Chemistry by Dr Anthony, WIX BLOG , ALL ABOUT DRUGS, WORLD DRUG TRACKER,MEDICINAL CHEM INTERNATIONAL, DRUG SYN INTERNATIONAL,SCALEUP OF DRUGS, ALL FOR DRUGSON WEB, are some most read chemistry blogs. Bacterial growth curve cultivation of anaerobs. In this experiment, Le Chatelier’s principle and esterification of the phenolic hydroxyl group of salicylic acid will be used to synthesize aspirin. 0000008424 00000 n 0000007403 00000 n First freshly... BACKGROUND Principle: Nuclophilic attack of amino group of urea towards one of the carbonyl group of phthalic anhydride forms... BACKGROUND Principle: Base catalyzed reaction between benzyl and urea is used for synthesis of phenytoin. This time the hydroxyl group of the salicylic acid acts as the nucleophile to attack the carbonyl group of the acetic anhydride and replace one of the acetyl groups.

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